https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32716 Wed 18 Jul 2018 16:33:36 AEST ]]> Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50847 Wed 09 Aug 2023 09:32:29 AEST ]]> Conservative or liberal oxygen therapy in adults after cardiac arrest: an individual-level patient data meta-analysis of randomised controlled trials https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38897 Tue 01 Mar 2022 15:34:13 AEDT ]]> Conservative versus liberal oxygenation targets for mechanically ventilated patients: a pilot multicenter randomized controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29228 2) of 88-92% (n = 52) or a liberal oxygenation strategy with target SpO₂ of greater than or equal to 96% (n = 51). MeasurementsandMainResults:Themean area under the curve and 95% confidence interval (CI) for SpO₂ (93.4% [92.9-93.9%] vs. 97% [96.5-97.5%]), SaO₂ (93.5% [93.1-94%] vs. 96.8% [96.3-97.3%]), PaO₂ (70 [68-73] mm Hg vs. 92 [89-96] mm Hg), and FIO₂ (0.26 [0.25-0.28] vs. 0.36 [0.34-0.39) in the conservative versus liberal oxygenation arm were significantly different (P < 0.0001 for all). There were no significant between-group differences in any measures of new organ dysfunction, or ICU or 90-day mortality. The percentage time spent with SpO₂ less than 88% in conservative versus liberal arm was 1% versus 0.3% (P = 0.03), and percentage time spent with SpO₂ greater than 98% in conservative versus liberal arm was 4% versus 22% (P < 0.001). The adjusted hazard ratio for 90-day mortality in the conservative arm was 0.77 (95% CI, 0.40-1.50; P = 0.44) overall and 0.49 (95% CI, 0.20-1.17; P = 0.10) in the prespecified subgroup of patients with a baseline PaO₂/FIO₂ less than 300. Conclusions: Our study supports the feasibility of a conservative oxygenation strategy in patients receiving IMV. Larger randomized controlled trials of this intervention appear justified.]]> Sat 24 Mar 2018 07:36:48 AEDT ]]> Angiotensin II for the treatment of vasodilatory shock https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31005 Mon 23 Sep 2019 10:08:51 AEST ]]> Conservative or liberal oxygen therapy for mechanically ventilated adults with acute brain pathologies: A post-hoc subgroup analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47387 Mon 16 Jan 2023 15:31:37 AEDT ]]> Selective digestive tract decontamination in critically ill adults with acute brain injuries: a post hoc analysis of a randomized clinical trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54600 Mon 04 Mar 2024 09:10:35 AEDT ]]>